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Artificial Intelligence (AI) and machine learning have advanced healthcare by defining relationships in complex conditions. Out-of-hospital cardiac arrest (OHCA) is a medically complex condition with several etiologies. Survival for OHCA has remained static at 10% for decades in the United States. Treatment of OHCA requires the coordination of numerous interventions, including the delivery of multiple medications. Current resuscitation algorithms follow a single strict pathway, regardless of fluctuating cardiac physiology. OHCA resuscitation requires a real-time biomarker that can guide interventions to improve outcomes. End tidal capnography (ETCO2) is commonly implemented by emergency medical services professionals in resuscitation and can serve as an ideal biomarker for resuscitation. However, there are no effective conceptual frameworks utilizing the continuous ETCO2 data. In this manuscript, we detail a conceptual framework using AI and machine learning techniques to leverage ETCO2 in guided resuscitation.